Title

The Golden Gene (Slc24A5) Differentiates Us Sub-Populations Within The Ethnically Admixed Y-Snp Haplogroups

Keywords

Admixture; Ethnogeographic ancestry; golden; Population differentiation; SLC24A5; Y-SNPs

Abstract

Y-SNPs are currently being investigated for their potential to predict the ethnogeographic origin of the donor of a crime scene sample. Unfortunately, due to the presence of genetically admixed individuals within ethnic sub-populations within a particular haplogroup (hg), it is sometimes difficult to predict the ethnogeographic ancestry of an individual using only Y-SNPs. In the present work we determine the feasibility of using a combination of the golden pigmentation gene (SLC24A5) SNP and recently described high resolution Y-SNP markers to distinguish some of the different ethnic groups within particular Y-SNP hgs. Four hundred twenty-four individuals (128 African, 206 European, 50 Hispanic/Latin, 20 Pakistan, 20 E.Asian/Indian) were typed for a SNP within the golden gene. The Y-SNP hg was determined for all males and it was found that many of the European derived hg possessed a significant amount of ethnic admixture, with R1b3 having the most. We show the use of the golden gene, in combination with more informative Y-SNPs (U152, U106, and M222) and those that define the major hg, can differentiate between most of the African vs. European and African vs. E. Asian members of these heterogeneous populations. © 2007 Elsevier Ireland Ltd. All rights reserved.

Publication Date

3-1-2008

Publication Title

Legal Medicine

Volume

10

Issue

2

Number of Pages

72-77

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.legalmed.2007.06.004

Socpus ID

37749002757 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/37749002757

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