Title

Evidence For The Effectiveness Of Botulinum Toxin For Spasmodic Dysphonia From High-Quality Research Designs

Keywords

Botulinum toxin; Spasmodic dysphonia

Abstract

The practice of evidence-based medicine promotes use of the knowledge ascertained from high quality research designs. The objective of this review was to determine what evidence has been provided from high quality research designs (e.g., randomized control trials or high quality prospective, matched group cohort studies), through December of 2006, relative to the effectiveness of botulinum toxin for treating spasmodic dysphonia. Results of the review indicated that no new high quality (Class I or Class II) studies have been published since 2001. One Class I study has been published since 1973, which found significant treatment effects for acoustic and perceptual variables of vocal function. Four Class II studies have been published during this same time frame, all finding significant treatment effects, though the nature of studied factors was variable between investigations. Based on the quality of evidence scale used, botulinum toxin can be considered an effective treatment for adductor spasmodic dysphonia. © 2007 Springer-Verlag.

Publication Date

4-1-2008

Publication Title

Journal of Neural Transmission

Volume

115

Issue

4

Number of Pages

625-630

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00702-007-0757-x

Socpus ID

42149179902 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/42149179902

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