Title
Utilization Of Fe 3+ -Acinetoferrin Analogs As An Iron Source By Mycobacterium Tuberculosis
Keywords
Acinetoferrin; Exosiderophores; Iron; Mycobacterium tuberculosis; Mycobactin; Siderophores
Abstract
Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential micronutrient). Successful iron acquisition allows M. tuberculosis to survive and proliferate under the iron-deficient conditions encountered in the host. To examine structural determinants important for iron siderophore transport in this pathogen, the citrate-based siderophores petrobactin, acinetoferrin and various acinetoferrin homologs were synthesized and used as iron transport probes. Mutant strains of M. tuberculosis deficient in native siderophore synthesis or transport were utilized to better understand the mechanisms involved in iron delivery via the synthetic siderophores. Acinetoferrin and its derivatives, especially those containing a cyclic imide group, were able to deliver iron or gallium into M. tuberculosis which promoted or inhibited, respectively, the growth of this pathogen. © 2007 Springer Science+Business Media, Inc.
Publication Date
1-1-2008
Publication Title
BioMetals
Volume
21
Issue
1
Number of Pages
93-103
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1007/s10534-007-9096-5
Copyright Status
Unknown
Socpus ID
38649102181 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/38649102181
STARS Citation
Rodriguez, G. Marcela; Gardner, Richard; Kaur, Navneet; and Phanstiel, Otto, "Utilization Of Fe 3+ -Acinetoferrin Analogs As An Iron Source By Mycobacterium Tuberculosis" (2008). Scopus Export 2000s. 10516.
https://stars.library.ucf.edu/scopus2000/10516