Title

Utilization Of Fe 3+ -Acinetoferrin Analogs As An Iron Source By Mycobacterium Tuberculosis

Keywords

Acinetoferrin; Exosiderophores; Iron; Mycobacterium tuberculosis; Mycobactin; Siderophores

Abstract

Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential micronutrient). Successful iron acquisition allows M. tuberculosis to survive and proliferate under the iron-deficient conditions encountered in the host. To examine structural determinants important for iron siderophore transport in this pathogen, the citrate-based siderophores petrobactin, acinetoferrin and various acinetoferrin homologs were synthesized and used as iron transport probes. Mutant strains of M. tuberculosis deficient in native siderophore synthesis or transport were utilized to better understand the mechanisms involved in iron delivery via the synthetic siderophores. Acinetoferrin and its derivatives, especially those containing a cyclic imide group, were able to deliver iron or gallium into M. tuberculosis which promoted or inhibited, respectively, the growth of this pathogen. © 2007 Springer Science+Business Media, Inc.

Publication Date

1-1-2008

Publication Title

BioMetals

Volume

21

Issue

1

Number of Pages

93-103

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s10534-007-9096-5

Socpus ID

38649102181 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/38649102181

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