Title

Orphan Seld Proteins And Selenium-Dependent Molybdenum Hydroxylases

Abstract

Bacterial and Archaeal cells use selenium structurally in selenouridine-modified tRNAs, in proteins translated with selenocysteine, and in the selenium-dependent molybdenum hydroxylases (SDMH). The first two uses both require the selenophosphate synthetase gene, selD. Examining over 500 complete prokaryotic genomes finds selD in exactly two species lacking both the selenocysteine and selenouridine systems, Enterococcus faecalis and Haloarcula marismortui. Surrounding these orphan selD genes, forming bidirectional best hits between species, and detectable by Partial Phylogenetic Profiling vs. selD, are several candidate molybdenum hydroxylase subunits and accessory proteins. We propose that certain accessory proteins, and orphan selD itself, are markers through which new selenium-dependent molybdenum hydroxylases can be found. © 2008 Haft and Self; licensee BioMed Central Ltd.

Publication Date

2-20-2008

Publication Title

Biology Direct

Volume

3

Number of Pages

-

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1186/1745-6150-3-4

Socpus ID

41549149124 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/41549149124

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