Title

Development Of Controlled Strength-Loss Resorbable Beta-Tricalcium Phosphate Bioceramic Structures

Keywords

Beta-tricalcium phosphate; Biaxial flexural test; Bioceramic; Biocompatibility; Pressure-less sintering; Sintering additives

Abstract

Controlling the strength-loss rate during biodegradation is a bottleneck in developing viable resorbable ceramic implants. Resorbable beta-tricalcium phosphate (β-TCP) bioceramic is known for its excellent biocompatibility. However, it exhibits poor sinterability and poor flexural strength. Here, we improved sintering behavior and biaxial flexural strength of β-TCP bioceramic without altering its biocompatibility by introducing multi-oxide sintering additives, in small quantities. These additives could also tailor the rate of resorption and hardness deterioration of β-TCP. A range of additives were prepared and introduced into β-TCP powder. Resultant powders were uniaxially pressed and sintered at 1250 °C, in air. Considerable improvement in densification (up to 33%) and biaxial flexural strength (up to 43%) were achieved. X-ray powder diffraction (XRD) analysis confirmed that the additives didn't alter the phase purity. In vitro cytotoxicity and biocompatibility analyses were performed using a prostate cancer cell-line. Results showed that the doped and pure β-TCP structures were non-toxic and biocompatible. © 2007 Elsevier B.V. All rights reserved.

Publication Date

4-1-2008

Publication Title

Materials Science and Engineering C

Volume

28

Issue

3

Number of Pages

392-398

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.msec.2007.04.007

Socpus ID

39749165292 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/39749165292

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