Title

How To Approach Alzheimer'S Disease Therapy Using Stem Cell Technologies

Keywords

Amyloid-β protein precursor; Mesenchymal stem cell; Nanog; Neuroreplacement; Phenserine

Abstract

The use of stem cells for neuroreplacement therapy is no longer science fiction - it is science fact. We have succeeded in producing neural cells in the brain using both neural and mesenchymal stem cell transplantation and even systemic injection using a small molecular compound. We have seen the improvement of cognitive function in animal models following the application of these stem cell technologies. These results may promise a bright future for stem cell based neuroreplacement therapies for neurodegenerative diseases including Alzheimer's disease (AD). However, we have to consider the pathophysiological environments of individual diseases before clinical applications can be introduced. We must find the factors in the pathology that may affect stem cell biology and overcome the negative effects on neuroreplacement. Here, we discuss not only the potential for therapeutic applications of stem cell strategies in neuropathological conditions, but also how to overcome the adverse effects on the biology of stem cells due to the factors that are altered under AD pathology. © 2008 - IOS Press and the authors. All rights reserved.

Publication Date

1-1-2008

Publication Title

Journal of Alzheimer's Disease

Volume

15

Issue

2

Number of Pages

241-254

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.3233/JAD-2008-15209

Socpus ID

54249117225 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/54249117225

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