Title
Stat3 As A Target For Inducing Apoptosis In Solid And Hematological Tumors
Keywords
Apoptosis; Cell growth; DNA-binding; Human tumors; Small-molecule inhibitors; STAT3
Abstract
Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented. © 2008 IBCB, SIBS, CAS All rights reserved.
Publication Date
2-1-2008
Publication Title
Cell Research
Volume
18
Issue
2
Number of Pages
254-267
Document Type
Review
Personal Identifier
scopus
DOI Link
https://doi.org/10.1038/cr.2008.18
Copyright Status
Unknown
Socpus ID
38849199799 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/38849199799
STARS Citation
Al Zaid Siddiquee, Khandaker and Turkson, James, "Stat3 As A Target For Inducing Apoptosis In Solid And Hematological Tumors" (2008). Scopus Export 2000s. 10988.
https://stars.library.ucf.edu/scopus2000/10988