Title

Stat3 As A Target For Inducing Apoptosis In Solid And Hematological Tumors

Keywords

Apoptosis; Cell growth; DNA-binding; Human tumors; Small-molecule inhibitors; STAT3

Abstract

Studies in the past few years have provided compelling evidence for the critical role of aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant transformation and tumorigenesis. Thus, it is now generally accepted that STAT3 is one of the critical players in human cancer formation and represents a valid target for novel anticancer drug design. This review focuses on aberrant STAT3 and its role in promoting tumor cell survival and supporting the malignant phenotype. A brief evaluation of the current strategies targeting STAT3 for the development of novel anticancer agents against human tumors harboring constitutively active STAT3 will also be presented. © 2008 IBCB, SIBS, CAS All rights reserved.

Publication Date

2-1-2008

Publication Title

Cell Research

Volume

18

Issue

2

Number of Pages

254-267

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/cr.2008.18

Socpus ID

38849199799 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/38849199799

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