Title

Cntf 1357 G → A Polymorphism And The Muscle Strength Response To Resistance Training

Keywords

Ciliary neurotrophic factor; Exercise; Genomics; Muscle mass

Abstract

The present study examined associations between the ciliary neurotrophic factor (CNTF) 1357 G → A polymorphism and the muscle strength response to a unilateral, upper arm resistance-training (RT) program among healthy, young adults. Subjects were 754 Caucasian men (40%) and women (60%) who were genotyped and performed a training program of the nondominant (trained) arm with the dominant (untrained) arm as a comparison. Peak elbow flexor strength was measured with one repetition maximum, isometric strength with maximum voluntary contraction, and bicep cross-sectional area with MRI in the trained and untrained arms before and after training. Women with the CNTF GG genotype gained more absolute isometric strength, as measured by MVC (6.5 ± 0.3 vs. 5.2 ±0.5 kg), than carriers of the CNTF A1357 allele in the trained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. Women with the CNTF GG genotype gained more absolute dynamic (1.0 ± 0.1 vs. 0.6 ± 0.1 kg) and allometric (0.022 ± 0.0 vs. 0.015 ± 0.0 kg/kg-0.67) strength, as measured by 1 RM, than carriers of the CNTF A1357 allele in the untrained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. No significant associations, as measured by cross-sectional area, were seen in men or women. The CNTF 1357 G 3 A polymorphism explains only a small portion of the variability in the muscle strength response to training in women. Copyright © 2009 the American Physiological Society.

Publication Date

10-1-2009

Publication Title

Journal of Applied Physiology

Volume

107

Issue

4

Number of Pages

1235-1240

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1152/japplphysiol.90835.2008

Socpus ID

70350120744 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/70350120744

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