Title

Plant-Made Vaccine Antigens And Biopharmaceuticals

Abstract

Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery. Plant-made vaccines have been developed for two decades but none has advanced beyond Phase I. However, two plant-made biopharmaceuticals are now advancing through Phase II and Phase III human clinical trials. In this review, we evaluate the advantages and disadvantages of different plant expression systems (stable nuclear and chloroplast or transient viral) and their current limitations or challenges. We provide suggestions for advancing this valuable concept for clinical applications and conclude that greater research emphasis is needed on large-scale production, purification, functional characterization, oral delivery and preclinical evaluation. © 2009 Elsevier Ltd. All rights reserved.

Publication Date

12-1-2009

Publication Title

Trends in Plant Science

Volume

14

Issue

12

Number of Pages

669-679

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.tplants.2009.09.009

Socpus ID

70549100034 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/70549100034

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