Title

Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles For Combined Targeted Cancer Therapy And Dual Optical/Magnetic Resonance Imaging

Keywords

Click chemistry; Drug delivery; Magnetic materials; Magnetic resonance imaging

Abstract

A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging andtargeted killing of folate-expressing cancer cells. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication Date

8-17-2009

Publication Title

Small

Volume

5

Issue

16

Number of Pages

1862-1868

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/smll.200900389

Socpus ID

69049104359 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/69049104359

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