Title

Protection From Radiation-Induced Pneumonitis Using Cerium Oxide Nanoparticles

Keywords

Nanoparticles; Pneumonitis; Quality of life; Radioprotection

Abstract

In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO2) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO2 nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO2 nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy. © 2009 Elsevier Inc. All rights reserved.

Publication Date

6-1-2009

Publication Title

Nanomedicine: Nanotechnology, Biology, and Medicine

Volume

5

Issue

2

Number of Pages

225-231

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.nano.2008.10.003

Socpus ID

67349277715 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/67349277715

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