Title

N-Alkylated Aminopyrazines For Use As Hydrophilic Optical Agents

Keywords

Fluorescence; GFR; Optical monitoring; PEG; Pyrazine; Reductive amination; Renal clearnce.; Renal function

Abstract

Rapid assessment of glomerular filtration rate (GFR), which measures the amount of plasma filtered through the kidney within a given time, would greatly facilitate monitoring of renal function for patients at the bedside in the clinic. In our pursuit to develop exogenous fluorescent tracers for real-time monitoring of renal function by optical methods, Nalkylated aminopyrazine dyes and their hydrophilic conjugates based on poly (ethylene glycol) (PEG) were synthesized via reductive amination as the key step. Photophysical properties indicated a bathochromic shift on the order of 50 nm in both absorption and emission compared to naked aminopyrazines which could be very useful in enhancing both tissue penetration as well as easier detection methods. Structure-activity relationship (SAR) and pharmacokinetic (PK) studies, and the correlation of in vivo optical data with plasma PK for measurement of clearance (and hence GFR) are focus of the current investigation. © 2009 SPIE.

Publication Date

6-15-2009

Publication Title

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volume

7190

Number of Pages

-

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1117/12.809287

Socpus ID

66749105829 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/66749105829

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