Title

Embryonic Stem Cells In Cardiac Repair And Regeneration

Abstract

Cell transplantation is a subject of fast-growing research with a potential of a therapeutic approach for the treatment of heart diseases. Clinical applications require preparation of large number of donor cells. Stem cell studies published to date demonstrate that scientists have not reached the general consensus to use an optimal cell type for better cardiac repair and regeneration. We used embryonic stem (ES) cells and their released factors for cardiac repair and regeneration. The major concern of cardiac regeneration with stem cells includes engraftment, differentiation, and teratoma formation after ES cell transplantation. Our current knowledge of ES cell transplantation in the heart is very limited. This review discusses the use of various growth factors to enhance ES cells engraftment and differentiation, as well as the issue of teratoma formation. © Copyright 2009, Mary Ann Liebert, Inc. 2009.

Publication Date

8-1-2009

Publication Title

Antioxidants and Redox Signaling

Volume

11

Issue

8

Number of Pages

1857-1863

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1089/ars.2009.2491

Socpus ID

67650257526 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/67650257526

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