Title

A Computational Model Of Membrane Lipid Electronic Properties In Relation To Neural Signaling

Keywords

Computational modeling; Hydrophobic mismatch; Lipids; Molecular computing; Neural membrane; Spectroscopy

Abstract

We present a computational model of a transiently-organized neural membrane molecular system with possible information-processing capacity. The model examines field-induced dipole and quadrupole moments and polarizability in monomeric, dimeric, and trimeric ethenes. Polarization of the ethenes is strongly indicated. This result is interpreted as a significant electronic feature of a molecular computing system based on organization of membrane lipids into a transient (∼10-4 s) crystalline state due to lipid-protein hydrophobic mismatch at the membrane-ion-channel interface. Predictive implications of the model's electronic features are briefly discussed. Copyright © 2001 Elsevier Science Ireland Ltd.

Publication Date

2-27-2001

Publication Title

BioSystems

Volume

59

Issue

1

Number of Pages

27-34

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/S0303-2647(00)00137-4

Socpus ID

0035131880 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0035131880

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