Title

Distribution Of Dna In Cationic Liposome Complexes Probed By Raman Microscopy

Abstract

The potential application of Raman microscopy to image the distribution of DNA inside lipid-DNA complexes was examined. To test this, we mixed DNA with DOTMA/DOPE liposome vesicles and imaged the distribution of DNA in the liposome complex by using the characteristic DNA guanine peak as a marker. The Raman intensity map indicates that the concentration of DNA molecules is higher near the core of the DOTMA/DOPE liposome vesicle. This result demonstrates that this technique is a viable technique to monitor DNA distribution inside liposomes.

Publication Date

2-6-2001

Publication Title

Langmuir

Volume

17

Issue

3

Number of Pages

571-573

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/la000437k

Socpus ID

0034831185 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0034831185

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