Title
Polymeric Nanoparticle Preparation That Eradicates Tumors
Abstract
We report the production of poly(lactic-co-glycolic acid) nanoparticles that encapsulate the photosensitizer meso-tetraphenylporpholactol. These nanoparticles are stable and nonphototoxic upon systemic administration. Upon cellular internalization, the photosensitizer is released from the nanoparticle and becomes highly phototoxic. Irradiation with visible light results in cell-specific killing of several cancer cell lines. Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizes with selective phototoxicity should have widespread applications in cancer therapy. © 2005 American Chemical Society.
Publication Date
12-1-2005
Publication Title
Nano Letters
Volume
5
Issue
12
Number of Pages
2552-2556
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1021/nl0519229
Copyright Status
Unknown
Socpus ID
30644466989 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/30644466989
STARS Citation
McCarthy, Jason R.; Perez, J. Manuel; and Brückner, Christian, "Polymeric Nanoparticle Preparation That Eradicates Tumors" (2005). Scopus Export 2000s. 3439.
https://stars.library.ucf.edu/scopus2000/3439