Title

Polymeric Nanoparticle Preparation That Eradicates Tumors

Abstract

We report the production of poly(lactic-co-glycolic acid) nanoparticles that encapsulate the photosensitizer meso-tetraphenylporpholactol. These nanoparticles are stable and nonphototoxic upon systemic administration. Upon cellular internalization, the photosensitizer is released from the nanoparticle and becomes highly phototoxic. Irradiation with visible light results in cell-specific killing of several cancer cell lines. Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizes with selective phototoxicity should have widespread applications in cancer therapy. © 2005 American Chemical Society.

Publication Date

12-1-2005

Publication Title

Nano Letters

Volume

5

Issue

12

Number of Pages

2552-2556

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/nl0519229

Socpus ID

30644466989 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/30644466989

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