Title

Controllable Self-Assembly Of Nanoparticles For Specific Delivery Of Multiple Therapeutic Molecules To Cancer Cells Using Rna Nanotechnology

Abstract

By utilizing RNA nanotechnology, we engineered both therapeutic siRNA and a receptor-binding RNA aptamer into individual pRNAs of phi29's motor. The RNA building block harboring siRNA or other therapeutic molecules was fabricated subsequently into a trimer through the interaction of engineered right and left interlocking RNA loops. The incubation of the protein-free nanoscale particles containing the receptor-binding aptamer or other ligands resulted in the binding and co-entry of the trivalent therapeutic particles into cells, subsequently modulating the apoptosis of cancer cells and leukemia model lymphocytes in cell culture and animal trials. The use of such antigenicity-free 20-40 nm particles holds promise for the repeated long-term treatment of chronic diseases. © 2005 American Chemical Society.

Publication Date

9-1-2005

Publication Title

Nano Letters

Volume

5

Issue

9

Number of Pages

1797-1808

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/nl051264s

Socpus ID

24944565527 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/24944565527

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