Title

Solid-Supported Synthesis Of Polymerizable Lanthanide-Ion Chelating Lipids For Protein Detection

Abstract

Usually, lipids are synthesized employing solution-phase organic synthesis techniques. Though successful, the purifications can be difficult to accomplish due to the amphiphilic nature of the molecules. Herein, we demonstrate the advantages of a solid-phase approach for preparing a variety of metal-chelating lipids. A number of saturated and polymerizable metal-chelating lipids were prepared using this methodology. This approach requires one Chromatographic purification after cleaving the lipids from the solid support. We also demonstrate that the resulting polymerized liposomes (containing Eu 3+) possess the appropriate luminescence properties for the qualitative and quantitative determination of proteins. © 2005 American Chemical Society.

Publication Date

4-7-2005

Publication Title

Inorganic Chemistry

Volume

44

Issue

7

Number of Pages

2234-2244

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/ic048885t

Socpus ID

16244377727 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/16244377727

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