Title

Ampa Receptor Subunit Glur2 Gates Injurious Signals In Ischemic Stroke

Keywords

AMPA receptors; CA1 neurons; Hippocampus; Ischemic stroke; Selective neuronal injury

Abstract

Ischemic stroke, or a brain attack, is the third leading cause of death in developed countries. A critical feature of the disease is a highly selective pattern of neuronal loss; certain identifiable subsets of neurons - particularly CA1 pyramidal neurons in the hippocampus - are severely damaged, whereas others remain intact. A key step in this selective neuronal injury is Ca 2+/Zn2+ entry into vulnerable neurons through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor channels, a principle subtype of glutamate receptors. AMPA receptor channels are assembled from glutamate receptor (GluR)1, -2, -3, and -4 subunits. Circumstance data have indicated that the GluR2 subunits dictate Ca 2+/Zn2+ permeability of AMPA receptor channels and gate injurious Ca2+/Zn2+ signals in vulnerable neurons. Therefore, targeting to the AMPA receptor subunit GluR2 can be considered a practical strategy for stroke therapy. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever reserved.

Publication Date

1-1-2005

Publication Title

Molecular Neurobiology

Volume

32

Issue

2

Number of Pages

145-155

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1385/MN:32:2:145

Socpus ID

25844438387 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/25844438387

This document is currently not available here.

Share

COinS