Title

Increased Bronchoalveolar Lavage Human Β-Defensin Type 2 In Bronchiolitis Obliterans Syndrome After Lung Transplantation

Keywords

Beta-defensin; Bronchiolitis obliterans; Lung transplantation

Abstract

Human β-defensin-2 (HBD)2 is an antimicrobial peptide that participates in the innate host immune defense. HBD2 is present in bronchoalveolar lavage (BAL) fluid during conditions associated with airway inflammation but not in normal subjects. We measured HBD2 concentrations by semiquantitative Western analysis in BAL of prelung transplant patients (PRE) and postlung-transplant BAL associated with either "quiescent" histopathology (i.e., without acute cellular rejection or infection) (NORMAL POST) or with bronchiolitis obliterans syndrome (BOS). HBD2 levels were not different for PRE (n=9) versus NORMAL POST-transplant BAL specimens (n=22) (204±180 vs. 82±60 pg/mL; P=NS). The BAL HBD2 concentrations were significantly elevated, however, with BOS (n=8) (1,270±430 pg/mL;P<0.001). HBD2 has been previously shown to elicit an adaptive immune response by means of recruitment of immature CD34+ dendritic cells and memory (CD4+/CD45RO+) T lymphocytes through interactions with their chemokine receptor, CCR6. Furthermore, HBD2 with CD 14 in human tracheobronchial epithelium can complex with "toll-like receptors" to activate the nuclear factor (NF)-κB pathway and therefore promote cytokine gene expression. We therefore speculate that complex interactions between adaptive and innate immunity may contribute to the propagation of airway inflammation in BOS.

Publication Date

10-27-2004

Publication Title

Transplantation

Volume

78

Issue

8

Number of Pages

1222-1224

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1097/01.TP.0000137265.18491.75

Socpus ID

7044264361 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/7044264361

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