Title

Lysozyme Levels In The Nasal Secretions Of Patients With Perennial Allergic Rhinitis And Recurrent Sinusitis

Abstract

Background: The association of perennial allergic rhinitis (PAR) with recurrent sinusitis (RS) is well recognized. Anatomic abnormalities at the osteomeatal complex or ciliary dysfunction may play a significant role in some patients. However, for most patients with allergy, the determinants of RS are unknown. Objective: To determine whether altered concentrations of antimicrobial peptides and proteins, such as lysozyme, lactoferrin, human β-defensin-2 (HBD-2), and human neutrophil peptides 1 to 3 (HNP-1 to 3), contribute to the development of RS in patients with PAR. Methods: Nasal secretions were collected by vacuum aspiration from 15 individuals with PAR+RS, 16 with PAR alone, and 16 controls. Lysozyme and lactoferrin levels were determined in nasal secretions by using quantitative enzyme-linked immunosorbent assay, and HBD-2 and HNP-1 to 3 levels were determined in nasal secretions by using semiquantitative Western blot analysis. Eosinophil-derived neurotoxin (EDN) levels were measured by using enzyme-linked immunosorbent assay as a marker of nasal eosinophilia in all 3 groups. Results: Levels of EDN were elevated significantly in patients with PAR+RS compared with controls. Lysozyme levels were decreased significantly in patients with PAR+RS compared with PAR alone or controls. Mean lysozyme levels were significantly lower in patients with EDN levels greater than 1,000 ng/mL vs those with levels of 1,000 ng/mL or less in the PAR+RS group. There were no statistically significant differences in lactoferrin, HBD-2, and HNP-1 to 3 levels among the 3 groups. Conclusions: The presence of eosinophils and their products and reduced lysozyme concentrations may be critical factors that predispose the airways of patients with PAR to RS.

Publication Date

1-1-2004

Publication Title

Annals of Allergy, Asthma and Immunology

Volume

93

Issue

3

Number of Pages

288-292

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/S1081-1206(10)61503-7

Socpus ID

4644235588 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/4644235588

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