Title

Prostate Cancer Risk And Esr1 Ta, Esr2 Ca Repeat Polymorphisms

Abstract

Background: Experimental evidence has suggested that estrogen receptor α (coded by the gene ESR1) might increase prostate cancer risk, whereas estrogen receptor B (coded by the gene ESR2) might reduce prostate cancer risk. Methods: We investigated the relationship with prostate cancer risk of both a TA repeat polymorphism in the ESR1 5′ region, ESR1 (TA)n, and with a CA repeat polymorphism in intron 5 of ESR2, ESR2 (CA)n, in a case-control study (545 cases and 674 controls) nested in the Physicians' Health Study. Results: Prostate cancer risk was highest for carriers of ESR1 (TA) 24 and ESR1 (TA)25. Replacing one modal ESR1 (TA) 14 allele with one ESR1 (TA)24 allele yielded an odds ratio of 1.42 (95% confidence interval, 1.00-2.00; P = 0.05). Replacing one ESR1 (TA)14 allele with one ESR1 (TA)25 allele yielded an odds ratio of 2.10 (95% confidence interval, 1.15-3.84; P = 0.02). ESR2 (CA) n showed no effects on prostate cancer risk. Conclusions: The ESR1 (TA)n polymorphism might play a role in prostate cancer risk. Copyright © 2007 American Association for Cancer Research.

Publication Date

11-1-2007

Publication Title

Cancer Epidemiology Biomarkers and Prevention

Volume

16

Issue

11

Number of Pages

2233-2236

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1158/1055-9965.EPI-07-0481

Socpus ID

38849178040 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/38849178040

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