Title

Assessment Of Predictions Submitted For The Casp7 Domain Prediction Category

Keywords

Ab initio domain prediction; Domain boundaries; Domain overlap; Evaluation; Proteins; Template-based domain prediction

Abstract

This paper details the assessment process and evaluation results for the Critical Assessment of Protein Structure Prediction (CASP7) domain prediction category. Domain predictions were assessed using the Normalized Domain Overlap score introduced in CASP6 and the accuracy of prediction of domain break points. The results of the analysis clearly demonstrate that the best methods are able to make consistently reliable predictions when the target has a structural template, although they are less good when the domain break occurs in a region not covered by a template. The conditions of the experiment meant that it was impossible to draw any conclusions about domain prediction for free modeling targets and it was also difficult to draw many distinctions between the best groups. Two thirds of the targets submitted were single domains and hence regarded as easy to predict. Even those targets defined as having multiple domains always had at least one domain with a similar template structure. © 2007 Wiley-Liss, Inc.

Publication Date

12-10-2007

Publication Title

Proteins: Structure, Function and Genetics

Volume

69

Issue

SUPPL. 8

Number of Pages

137-151

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/prot.21675

Socpus ID

36749014942 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/36749014942

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