Title

Role Of KAtp Channels In Protection Against Neuronal Excitatory Insults

Keywords

Epilepsy; Excitotoxicity; Glutamate; Ischemia; K ATP; Synaptic degeneration

Abstract

ATP-sensitive K+ (KATP) channels that are gated by intracellular ATP/ADP concentrations are a unique subtype of potassium channels and play an essential role in coupling intracellular metabolic events to electrical activity. Opening of KATP channels during energy deficits in the CNS induces efflux of potassium ions and in turn hyperpolarizes neurons. Thus, activation of KATP channels is thought to be able to counteract excitatory insults and protect against neuronal death. In this review, we bring together recent studies about what kinds of molecules are needed to build and regulate arrays of KATP channel functions in the CNS neurons. We propose a model to explain how KATP channel activation regulates glutamate release from the pre-synaptic terminals and how this regulation protects against ischemic neuronal injury and epilepsy. © 2007 The Authors.

Publication Date

12-1-2007

Publication Title

Journal of Neurochemistry

Volume

103

Issue

5

Number of Pages

1721-1729

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/j.1471-4159.2007.04963.x

Socpus ID

36249010402 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/36249010402

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