Title

Fabrication Of Ultrathin Polyelectrolyte Fibers And Their Controlled Release Properties

Keywords

Cationic molecules; Controlled release; Electrospun; Weak polyelectrolytes

Abstract

Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science. © 2007 Elsevier B.V. All rights reserved.

Publication Date

8-1-2007

Publication Title

Colloids and Surfaces B: Biointerfaces

Volume

58

Issue

2

Number of Pages

172-179

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.colsurfb.2007.03.004

Socpus ID

34250303510 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/34250303510

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