Title
Reelin Expression Is Upregulated Following Ocular Tissue Injury
Keywords
Cornea; Migration; Reelin; Regeneration; Retina; Stem cell
Abstract
Purpose: Reelin is important in the guidance of neuronal stem cells in the central nervous system during normal development. We wished to determine whether reelin is expressed in the retina and cornea after injury. Methods: Mice underwent laceration of their retina as well as corneal epithelial debridement. The mice were sacrificed at 3 days, and eyes were fixed and stained for reelin expression and reelin messenger ribonucleic acid (mRNA). Results: In normal eyes, reelin was expressed only at very low levels in the ganglion cell layer of the retina and the endothelial cell layer of the cornea. In injured eyes, there was marked expression in reelin immunoreactivity in the retina and cornea. Reelin gene expression was seen in the retina and cornea. Conclusions: Reelin is expressed during normal retinogenesis. This study shows that reelin is also upregulated following injury to the retina and cornea. The expression of reelin following injury suggests that reelin may play an important role in regulating stem cell trafficking in neuronal and nonneuronal tissues following injury similar to its role in normal organogenesis. © Springer-Verlag 2006.
Publication Date
6-1-2007
Publication Title
Graefe's Archive for Clinical and Experimental Ophthalmology
Volume
245
Issue
6
Number of Pages
889-893
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1007/s00417-006-0458-4
Copyright Status
Unknown
Socpus ID
34249314005 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/34249314005
STARS Citation
Pulido, Jose S.; Sugaya, Ikuko; Comstock, Jordan; and Sugaya, Kiminobu, "Reelin Expression Is Upregulated Following Ocular Tissue Injury" (2007). Scopus Export 2000s. 6564.
https://stars.library.ucf.edu/scopus2000/6564