Title

Nanocrystalline Hydroxyapatite Doped With Magnesium And Zinc: Synthesis And Characterization

Keywords

Biomaterial; Calcium phosphate; Nano-powder; Nanocrystalline hydroxyapatite; Nanostructured bioceramics; Sol-Gel

Abstract

During recent years, there have been efforts in developing nanocrystalline bioceramics, to enhance their mechanical and biological properties for use in tissue engineering applications. In this research, we made an attempt to synthesize nanocrystalline bioactive hydroxyapatite (Ca10(PO4)6(OH)2, HAp) ceramic powder in the lower-end of nano-range (2-10 nm), using a simple low-temperature sol-gel technique and studied its densification behavior. We further studied the effects of metal ion dopants during synthesis on powder morphology, and the properties of the sintered structures. Calcium nitrate and triethyl phosphite were used as precursors for calcium and phosphorous, respectively, for sol-gel synthesis. Calculated quantities of magnesium oxide and zinc oxide were incorporated as dopants into amorphous dried powder, prior to calcination at 250-550 °C. The synthesized powders were analyzed for their phases using X-ray diffraction technique and characterized for powder morphology and particle size using transmission electron microscopy (TEM). TEM analysis showed that the average particle size of the synthesized powders were in the range of 2-10 nm. The synthesized nano-powders were uniaxially compacted and then sintered at 1250 °C and 1300 °C for 6 h, separately, in air. A maximum average sintered density of 3.29 g/cm3 was achieved in structures sintered at 1300 °C, developed from nano-powder doped with magnesium. Vickers hardness testing was performed to determine the hardness of the sintered structures. Uniaxial compression tests were performed to evaluate the mechanical properties. Bioactivity and biodegradation behavior of the sintered structures were assessed in simulated body fluid (SBF) and maintained in a dynamic state. © 2006 Elsevier B.V. All rights reserved.

Publication Date

5-16-2007

Publication Title

Materials Science and Engineering C

Volume

27

Issue

4

Number of Pages

837-848

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.msec.2006.09.036

Socpus ID

34247202186 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/34247202186

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