Title

The Retrocyclin Analogue Rc-101 Prevents Human Immunodeficiency Virus Type 1 Infection Of A Model Human Cervicovaginal Tissue Construct

Keywords

θ-defensin; Acquired immunodeficieny syndrome; Antimicrobial peptide; Human immunodeficiency virus; Microbicide; Vagina

Abstract

Retrocyclins are cyclic antimicrobial peptides that exhibit potent activity towards a broad range of primary and laboratory-adapted strains of human immunodeficiency virus type 1 (HIV-1) in vitro. The current study shows that RC-101, an analogue of retrocyclin, prevented HIV-1 infection in an organ-like construct of human cervicovaginal tissue and retained full activity in the presence of vaginal fluid. The peptide remained within the cervicovaginal tissues throughout the 9-day incubation period without altering tissue viability, inducing damage or inducing the release of inflammatory cytokines. Collectively, these data support the potential development of RC-101 as a topical microbicide to prevent HIV-1 infection and transmission. © 2007 Blackwell Publishing Ltd.

Publication Date

5-1-2007

Publication Title

Immunology

Volume

121

Issue

1

Number of Pages

140-145

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/j.1365-2567.2006.02553.x

Socpus ID

34047228602 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/34047228602

This document is currently not available here.

Share

COinS