Title

Integration Of Living Cells With Silicon Nanostructures For Mems Applications

Keywords

Cell patterning; Cell-electrode interface; Engineered neuronal networks; MEMS; Multi-electrode arrays; Photolithography; Self-assembled monolayer; Skeletal muscle engineering

Abstract

For many years biological and silicon-based structures were considered incompatible because of the difficulties to engineer an effective interface connecting the two systems. Recent developments in surface chemistry, bioengineering and cell biology enabled the creation of extracellular clues to guide the attachment and growth of cells on silicon structures. We have developed a photolithography-based method, which was compatible with standard silicon manufacturing steps, to pattern self-assembled monolayers (SAMs) on glass or silicon substrates to guide cell attachment, pattern formation and differentiation. In order to demonstrate the effectiveness of our method to create functional cellular networks on silicon microstructures we have registered the surface patterns with substrate embedded micro electrodes to allow long-term recording of activity of the cells or electrical stimulation. These hybrid biological/silicon-based systems can find applications in functional pharmacological screening, toxin detection, as disease models or in robotics.

Publication Date

8-23-2007

Publication Title

2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

Volume

2

Number of Pages

737-740

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

Socpus ID

34547969467 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/34547969467

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