Title

Diacyltrehalose Of Mycobacterium Tuberculosis Inhibits Lipopolysaccharide- And Mycobacteria-Induced Proinflammatory Cytokine Production In Human Monocytic Cells

Keywords

Cytokines; Diacyltrehalose; Monocytes; Mycobacterium tuberculosis

Abstract

The lipids located in the outer layer of Mycobacterium tuberculosis, which include sulfolipid, phthiocerol dimycocerosate (PDIM), diacyltrehalose, and polyacyltrehalose, may play a role in host-pathogen interactions. These lipids were purified using thin-layer chromatography, and their ability to induce proinflammatory cytokines in human monocytes and in a human acute monocytic leukemia cell line (THP-1) was examined. None of the lipids tested induced significant interleukin (IL)-12p40 or tumor necrosis factor (TNF)-α production in monocytic cells. Diacyltrehalose significantly inhibited lipopolysaccharide- and M. tuberculosis-induced IL-12p40, TNF-α, and IL-6 productions in human monocytes, whereas other lipids had no effect. However, diacyltrehalose was unable to inhibit peptidoglycan-induced IL-12p40 production. These results suggest that diacyltrehalose is a mycobacterial factor capable of modulating host immune responses. © 2006 Federation of European Microbiological Societies.

Publication Date

2-1-2007

Publication Title

FEMS Microbiology Letters

Volume

267

Issue

1

Number of Pages

121-128

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/j.1574-6968.2006.00553.x

Socpus ID

33846069190 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33846069190

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