Title

Tumor Microenvironment And Angiogenesis

Abstract

The major clinical challenge of systemic cancer therapy is not eradication of the primary tumor, which can be treated with radiation or surgery, but eradication of metastases, which are usually present at the time of initial diagnosis and are likely to be resistant to conventional chemotherapy (1-3). A principal barrier to the destruction of disseminated cancer is the heterogeneous nature of cancer. This heterogeneity is exhibited in a wide range of biologic entities such as cell-surface receptors, enzymes, and karyotypes, and in cellular features, such as morphologic characteristics, growth properties, sensitivity to chemotherapeutic drugs, and the ability to invade and metastasize (3,4-6). Neoplastic transformation involves genetic alterations, such as the activation or dysregulation of oncogenes (7), and cells that are able to circumvent normal growth-control mechanisms may undergo continuous selection pressures. Unfortunately, this continuous evolution of genetically unstable neoplasms eventually favors the emergence of subpopulations of cells with metastatic potential.

Publication Date

1-1-2007

Publication Title

Antiangiogenic Cancer Therapy

Number of Pages

131-148

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1201/9781420004298

Socpus ID

44649093826 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/44649093826

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