Title

Sub-Populations Within The Major European And African Derived Haplogroups R1B3 And E3A Are Differentiated By Previously Phylogenetically Undefined Y-Snps.

Abstract

Single nucleotide polymorphisms on the Y chromosome (Y-SNPs) have been widely used in the study of human migration patterns and evolution. Potential forensic applications of Y-SNPs include their use in predicting the ethnogeographic origin of the donor of a crime scene sample, or exclusion of suspects of sexual assaults (the evidence of which often comprises male/female mixtures and may involve multiple perpetrators), paternity testing, and identification of non- and half-siblings. In this study, we used a population of 118 African- and 125 European-Americans to evaluate 12 previously phylogenetically undefined Y-SNPs for their ability to further differentiate individuals who belong to the major African (E3a)- and European (R1b3, I)-derived haplogroups. Ten of these markers define seven new sub-clades (equivalent to E3a7a, E3a8, E3a8a, E3a8a1, R1b3h, R1b3i, and R1b3i1 using the Y Chromosome Consortium nomenclature) within haplogroups E and R. Interestingly, during the course of this study we evaluated M222, a sub-R1b3 marker rarely used, and found that this sub-haplogroup in effect defines the Y-STR Irish Modal Haplotype (IMH). The new bi-allelic markers described here are expected to find application in human evolutionary studies and forensic genetics. (c) 2006 Wiley-Liss, Inc.

Publication Date

1-1-2007

Publication Title

Human mutation

Volume

28

Issue

1

Number of Pages

97-

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/humu.9469

Socpus ID

34548242317 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/34548242317

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