Title

Listeria Monocytogenes

Keywords

Genomics; Internalins; Leucine-rich repeat; Lipoprotein; Listeria monocytogenes; Listeriosis; LPXTG; PrfA; Sortase; Surface protein

Abstract

Listeria monocytogenes is a Gram-positive, intracellular bacterial pathogen responsible for severe food-borne illnesses resulting in central nervous system infection or abortion. L. monocytogenes induces its own internalization into mammalian cells, escapes from the host cell phagosome, replicates extensively in the cytosol, and spreads from one host cell to another through an F-actin-dependent motility process. Previously, classical genetic approaches were used to identify bacterial virulence factors critical for the intracellular life cycle of L. monocytogenes. The recent availability of the nucleotide sequence of L. monocytogenes has provided the potential for global analysis of bacterial proteins that affect pathogenesis. In this chapter, ways in which the L. monocytogenes genome has been used to probe the functions of bacterial proteins in virulence is discussed. At the end of the chapter, future genomic-or proteomic-based approaches that might improve or expand on current work are highlighted. © 2006 Humana Press Inc.

Publication Date

12-1-2006

Publication Title

Bacterial Genomes and Infectious Diseases

Number of Pages

125-149

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/978-1-59745-152-9_8

Socpus ID

84885794482 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84885794482

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