Title

Reflex-Arc On A Chip: An In Silico Cell Culture Analogue

Keywords

Cell culture; MEMS; Muscle; Neuron; Silane

Abstract

Treatment and understanding of traumatic spinal cord injury (SCI) and neurodegenerative diseases have been problematic due in part to difficulties associated with the various models used to test new drug therapies. Animal studies are expensive, time consuming, and can raise ethical issues. In vitro studies avoid many of the issues associated with animal studies and can allow the use of human cells, but such data are too incomplete to be predictors of human response due to the lack of interaction between tissues and differences between culture and physiological dynamics. To overcome the shortcomings of existing models we are developing a microscopic cell culture analogue (microCCA) of the spinal reflex-arc. This system will provide a model which can accurately reflect important aspects of in vivo behavior of animal models, but retain the cost effectiveness of in vitro models as well as the ability to perform large numbers of tests in parallel.

Publication Date

12-8-2006

Publication Title

2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings

Volume

2

Number of Pages

297-300

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

Socpus ID

33845199701 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33845199701

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