Title

Organization Of Peptide Nanotubes Into Macroscopic Bundles

Abstract

A simple chemical method to assemble peptide nanotubes and simultaneously arrange them into macroscopic bundles is reported. The peptide nanotubes, self-assemblies of the bolaamphiphilic peptide monomer bis(N-α-amido-glycylglycine)-1,7-heptane dicarboxylate, appeared in acidic solution within 1 week. In the presence of Ni2+ ions, the bolaamphiphile peptide assembles into well-organized macroscopic bundles of the peptide nanotubes. Addition of EDTA to a suspension of peptide nanotube bundles resulted in disassembly of the bundles into peptide nanotubes with diameters between 40 and 140 nm. A majority of the free amide sites of the peptide nanotubes were involved in the intercalation of nickel ions, which act as bridges to bundle adjacent peptide nanotubes. The covalent bridge of Ni2+ ions with amide groups of the peptide nanotube was confirmed by Raman microscopy.

Publication Date

12-11-2001

Publication Title

Langmuir

Volume

17

Issue

25

Number of Pages

7918-7922

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/la010910+

Socpus ID

0035846780 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0035846780

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