Title

Dynamic-Focusing Microscope Objective For Optical Coherence Tomography

Keywords

Bio-medical imaging; Dynamic focusing; Optical coherence microscopy; Optical coherence tomography; Skin cancer

Abstract

Optical Coherence Tomography (OCT) is a novel optical imaging technique that has assumed significant importance in bio-medical imaging in the last two decades because it is non-invasive and provides accurate, high resolution images of three dimensional cross-sections of body tissue, exceeding the capabilities of the current predominant imaging technique -ultrasound. In this paper, the application of high resolution OCT, known as optical coherence microscopy (OCM) is investigated for in vivo detection of abnormal skin pathology for the early diagnosis of cancer. A main challenge in OCM is maintaining invariant resolution throughout the sample. The technology presented is based on a dynamic focusing microscope imaging probe conceived for skin imaging and the detection of abnormalities in the epithelium. A novel method for dynamic focusing in the biological sample is presented using variable-focus lens technology to obtain three dimensional images with invariant resolution throughout the crosssection and depth of the sample is presented and discussed. A low coherence broadband source centered at near IR wavelengths is used to illuminate the sample. The design, analysis and predicted performance of the dynamic focusing microscope objective designed for dynamic three dimensional imaging at Sum resolution for the chosen broadband spectrum is presented. © 2006 SPIE-OSA.

Publication Date

10-19-2006

Publication Title

Proceedings of SPIE - The International Society for Optical Engineering

Volume

6342 I

Number of Pages

-

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1117/12.692205

Socpus ID

33749868291 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33749868291

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