Title

Murine Cytomegalovirus Infection Markedly Reduces Serum Mcp-1 Levels In Mcp-1 Transgenic Mice

Keywords

Atherosclerosis; Cytokines; Cytomegalovirus; Monocyte chemoattractant protein-1

Abstract

Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory chemokine believed to play a major role in atherogenesis. Injured endothelial cells express MCP-1, which attracts monocytes to the blood vessel wall and leads to the formation of atheromas. Cytomegalovirus infection may also play a role in atherogenesis and accelerates inflammation in tissues that overexpress MCP-1. To examine the relationship of cytomegalovirus infection and MCP-1, we infected MCP-1 transgenic mice with murine cytomegalovirus (MCMV) and collected serum 6 days post-infection to evaluate TH1-related cytokine levels by ELISA. Serum levels of IL-10, IL-12 and IFN-γ were increased in MCP-1 transgenic mice on day 6 following MCMV infection, while levels of IL-1β and TNF-α were undetectable. However, MCP-1 serum levels were reduced >50% in MCP-1 transgenic mice following MCMV infection compared to uninfected transgenic mice. This effect was not as dramatic when an M33 null MCMV was administered to MCP-1 transgenic mice. The mechanism by which MCMV lowers serum MCP-1 levels is unknown, but this effect may enhance the survival of the virus and thus allow CMV to contribute to the chronic inflammation of atherogenesis. © 2006 by the Association of Clinical Scientists, Inc.

Publication Date

3-1-2006

Publication Title

Annals of Clinical and Laboratory Science

Volume

36

Issue

2

Number of Pages

179-184

Document Type

Article

Personal Identifier

scopus

Socpus ID

33646529133 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33646529133

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