Title

Gold-Speckled Multimodal Nanoparticles For Noninvasive Bioimaging

Abstract

In this report the synthesis, characterization, and functional evaluation of a multimodal nanoparticulate contrast agent for noninvasive imaging through both magnetic resonance imaging (MRI) and photoacoustic tomography (PAT) is presented. The nanoparticles described herein enable high resolution and highly sensitive three-dimensional diagnostic imaging through the synergistic coupling of MRI and PAT capabilities. Gadolinium (Gd)-doped gold-speckled silica (GSS) nanoparticles, ranging from 50 to 200 nm, have been prepared in a simple one-pot synthesis using nonionic microemulsions. The photoacoustic signal is generated from a nonuniform, discontinuous gold nanodomains speckled across the silica surface, whereas the MR contrast is provided through Gd incorporated in the silica matrix. The presence of a discontinuous speckled surface, as opposed to a continuous gold shell, allows sufficient bulk water exchange with the Gd ions to generate a strong MR contrast. The dual imaging capabilities of the particles have been demonstrated through in silicio and in vitro methods. The described particles also have the capacity for therapeutic applications including the thermal ablation of tumors through the absorption of irradiated light. © 2008 American Chemical Society.

Publication Date

10-14-2008

Publication Title

Chemistry of Materials

Volume

20

Issue

19

Number of Pages

6087-6094

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/cm801020s

Socpus ID

54849425759 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/54849425759

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