Title

Redox-Active Radical Scavenging Nanomaterials

Abstract

Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, likely through their direct reaction with superoxide radical, since each of these materials has been shown to act as effective superoxide dismutase mimetics in vitro. This critical review discusses the chemistry of these nanomaterials and the context in which their radical scavenging activities have been studied in biological model systems. Current studies are focused on determining the uptake, metabolism, distribution, toxicity and fate of these nanomaterials in cell and animal model systems. Ultimately if shown to be safe, these nanomaterials have the potential to be used to reduce the damaging effects of radicals in biological systems (101 references). © 2011 The Royal Society of Chemistry.

Publication Date

10-19-2010

Publication Title

Chemical Society Reviews

Volume

39

Issue

11

Number of Pages

4422-4432

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/b919677n

Socpus ID

77958067246 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77958067246

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