Title

Anti-Inflammatory Therapy For Alzheimer'S Disease From Epidemiological Fact To New Mechanisms Of Action

Keywords

Alzheimer's disease; Anti-inflammatory drugs; Inflammation

Abstract

While the exact causes or mechanisms of Alzheimer's disease (AD) are still not known, the most critical risk factor is aging. Cellular oxidative stress is known to occur in the brain during aging and some pathology of AD could be explained by the oxidative stress, including senile plaques, deposition of amyloid peptide (Aβ) and tangles (deposition of an abnormally phosphorylated tau). Also gliosis, which may release inflammatory molecules and cause oxidative stress, is a feature of aging and AD. Epidemiological analysis indicates that people with severe arthritis and who are subjected to leprosy therapy have significantly lower rates of AD. Since both arthritis and leprosy therapy involves high doses of nonsteroidal anti-inflammatory drugs (NSAIDs), and the fact that inflammation is involved in AD pathology, NSAID-therapy might prevent or delay the onset of AD. More recently NSAIDs were found to reduce production of Aβ peptide. Therefore, we should revisit NSAIDs as potential treatment for AD therapy. There are clinical studies showing the beneficial effects of NSAIDs treatments in AD patients, in contrast, other studies show a lack of benefit. This article discusses the role of inflammation and oxidative stress in AD and the role of drugs preventing them. © 2010 Bentham Science Publishers Ltd.

Publication Date

1-1-2010

Publication Title

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Volume

9

Issue

3

Number of Pages

189-196

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.2174/1871523011009030189

Socpus ID

77958514240 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77958514240

This document is currently not available here.

Share

COinS