Title
Real-Time Snp Analysis In Secondary-Structure-Folded Nucleic Scids
Keywords
biotransformations; genotyping; molecular beacons; real-time detection; tau proteins
Abstract
A tricomponent sensor was designed for genotyping stem-loop-structured DNA sequences. DNA adaptor strand f (see picture; red) hybridizes to the analyte (orange) with high affinity and unwinds its secondary structure; strand m (green) forms a stable complex only with the fully complementary analyte sequence. A fluorescing molecular beacon reports complex formation. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication Date
11-15-2010
Publication Title
Angewandte Chemie - International Edition
Volume
49
Issue
47
Number of Pages
8950-8953
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1002/anie.201004475
Copyright Status
Unknown
Socpus ID
78449232383 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/78449232383
STARS Citation
Grimes, Jeffrey; Gerasimova, Yulia V.; and Kolpashchikov, Dmitry M., "Real-Time Snp Analysis In Secondary-Structure-Folded Nucleic Scids" (2010). Scopus Export 2010-2014. 146.
https://stars.library.ucf.edu/scopus2010/146