Title

A Fluid-Structure Interaction Index Of Coronary Plaque Rupture

Keywords

Fluid-structure interaction; Non-linear elasticity; Plaque rupture; Stenosis

Abstract

The impact of coupled blood flow and structural dynamics on coronary plaque is investigated with the objective of defining a unique index for characterizing plaque rupture. Two-dimensional non-circular lumen models of native, moderate and severely stenosed human coronary arteries are investigated. The flow and structural analyses are performed simultaneously using well-validated commercial software. New flow-structure interaction (FSI) indices are defined by normalizing the predicted hemodynamic shear stress with the structural stresses. The results predict that the plaques investigated are potentially vulnerable to rupture at 40-45% stenosis levels. The predicted trend is consistent with clinical observations, indicating that the selected FSI index has the potential to characterize plaque rupture when properly established. © 2010 Springer-Verlag.

Publication Date

3-25-2010

Publication Title

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Volume

5958 LNCS

Number of Pages

98-107

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/978-3-642-11615-5_11

Socpus ID

77949576903 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77949576903

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