Title

Nanobioimaging And Sensing Of Infectious Diseases

Keywords

Bacterial detection; Colorimetric assay; Fluorescent nanoparticles; Immunomagnetic separation; Magnetic nanosensors; Multiplexing; Surface plasmon resonance; Viral imaging

Abstract

New methods to identify trace amount of infectious pathogens rapidly, accurately and with high sensitivity are in constant demand to prevent epidemics and loss of lives. Early detection of these pathogens to prevent, treat and contain the spread of infections is crucial. Therefore, there is a need and urgency for sensitive, specific, accurate, easy-to-use diagnostic tests. Versatile biofunctionalized engineered nanomaterials are proving to be promising in meeting these needs in diagnosing the pathogens in food, blood and clinical samples. The unique optical and magnetic properties of the nanoscale materials have been put to use for the diagnostics. In this review, we focus on the developments of the fluorescent nanoparticles, metallic nanostructures and superparamagnetic nanoparticles for bioimaging and detection of infectious microorganisms. The various nanodiagnostic assays developed to image, detect and capture infectious virus and bacteria in solutions, food or biological samples in vitro and in vivo are presented and their relevance to developing countries is discussed. © 2009 Elsevier B.V. All rights reserved.

Publication Date

3-18-2010

Publication Title

Advanced Drug Delivery Reviews

Volume

62

Issue

4-5

Number of Pages

424-437

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.addr.2009.11.014

Socpus ID

76849099053 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/76849099053

This document is currently not available here.

Share

COinS