Title
Coordination Complex Sh2 Domain Proteomimetics: An Alternative Approach To Disrupting Oncogenic Protein-Protein Interactions
Abstract
We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(ii) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity. © The Royal Society of Chemistry 2010.
Publication Date
1-1-2010
Publication Title
Chemical Communications
Volume
46
Issue
6
Number of Pages
892-894
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1039/b919608k
Copyright Status
Unknown
Socpus ID
75649128334 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/75649128334
STARS Citation
Drewry, Joel A.; Fletcher, Steven; Yue, Peibin; Marushchak, Denys; and Zhao, Wei, "Coordination Complex Sh2 Domain Proteomimetics: An Alternative Approach To Disrupting Oncogenic Protein-Protein Interactions" (2010). Scopus Export 2010-2014. 1840.
https://stars.library.ucf.edu/scopus2010/1840