Title

Cytotoxic And Genotoxic Assessment Of Glycolipid-Reduced And -Capped Gold And Silver Nanoparticles

Abstract

A systematic cytotoxic and genotoxic evaluation of glycolipid-conjugated silver and gold nanoparticles is carried out. These glycolipid nanoparticle conjugates are obtained by exploiting the reductive capability of a class of glycolipids called sophorolipids that play the role of capping agent as well. Further, when tested for their cytotoxicity and genotoxicity on HepG2 cells, these nanoparticles are found to be cytocompatible up to 100 μM metal concentrations. Of the two metallic systems investigated, gold nanoparticles are found to be more cytocompatible than the same concentrations of silver nanoparticles. Similarly, it is also demonstrated that at 100 μM, silver nanoparticles cause more DNA damage compared to gold nanoparticles of similar concentrations. © 2010 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Publication Date

1-1-2010

Publication Title

New Journal of Chemistry

Volume

34

Issue

2

Number of Pages

294-301

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/b9nj00277d

Socpus ID

76149100273 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/76149100273

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