Title

From Rational Design To Probe Optimization: The Role Of Nanoparticle Valency In Single Cancer Cell Detection In Blood Via Magnetic Relaxation

Keywords

Bacteria; Iron oxide nanoparticles; Mammalian cells; Small molecule probes

Abstract

The conjugation of targeting ligands to iron oxide nanoparticles has achieved the development of specific assays for the detection of biomedical targets through magnetic relaxation. However, limited studies investigated how the nanoparticle valency modulates the detection response and the assays' sensitivity. Through nanoparticle valency grafting, we were able to achieve single cancer cell detection in blood, with a small-molecule-carrying multivalent nanoparticle in just 15 minutes. Although exhibiting a similar diagnostic trend, a corresponding high-valency antibody-carrying nanosensor did not achieve the same detection threshold, indicating that small molecules might be attractive probes for cancer diagnostics. Overall, these studies indicate that nanoparticle multivalency is a critical parameter in the design of robust and sensitive nanoprobes for diverse clinical and field-based applications.

Publication Date

11-23-2011

Publication Title

Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011

Volume

3

Number of Pages

14-15

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

Socpus ID

81455140014 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/81455140014

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