Title

Incorporation Of The Hiv-1 Microbicide Cyanovirin-N In A Food Product

Keywords

CV-N; cyanovirin-N; HIV-1; lactic acid bacteria; microbicide; pigtail macaque

Abstract

An urgent need exists for HIV-1 microbicides. Here, we describe the in vivo testing of lactic acid bacteria bioengineered to secrete cyanovirin-N. We fed pigtail macaques a yogurt formulation that used bioengineered strains as a starter culture. Cyanovirin-N expression could be detected in the rectal vault during and immediately after feeding. Ex vivo viral challenge of rectal tissue biopsies revealed that peak viral burden was significantly lower in tissue obtained from experimental animals compared with control animals. Formulation of candidate compounds in lactic acid bacteria and their oral administration seems to be a feasible strategy for mucosal delivery of microbicides. © 2011 Lippincott Williams & Wilkins.

Publication Date

12-1-2011

Publication Title

Journal of Acquired Immune Deficiency Syndromes

Volume

58

Issue

4

Number of Pages

379-384

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1097/QAI.0b013e31823643fe

Socpus ID

80255137600 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/80255137600

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