Title

Toward An Integrated Knowledge Environment To Support Modern Oncology

Keywords

biomarkers; Informatics; integration; knowledge environment; next-generation sequencing; oncology; outcomes; patient; treatment

Abstract

Around the world, teams of researchers continue to develop a wide range of systems to capture, store, and analyze data including treatment, patient outcomes, tumor registries, next-generation sequencing, single-nucleotide polymorphism, copy number, gene expression, drug chemistry, drug safety, and toxicity. Scientists mine, curate, and manually annotate growing mountains of data to produce high-quality databases, while clinical information is aggregated in distant systems. Databases are currently scattered, and relationships between variables coded in disparate datasets are frequently invisible. The challenge is to evolve oncology informatics from a "systems" orientation of standalone platforms and silos into an "integrated knowledge environments" that will connect "knowable" research data with patient clinical information. The aim of this article is to review progress toward an integrated knowledge environment to support modern oncology with a focus on supporting scientific discovery and improving cancer care. Copyright © 2011 by Lippincott Williams & Wilkins.

Publication Date

7-1-2011

Publication Title

Cancer Journal

Volume

17

Issue

4

Number of Pages

257-263

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1097/PPO.0b013e31822c390b

Socpus ID

80051755297 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/80051755297

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