Title

Artificially Induced Protein-Membrane Anchorage With Cholesterol-Based Recognition Agents As A New Therapeutic Concept

Keywords

antitumor agents; drug design; nuclear-translocation inhibitors; protein-membrane anchorage; protein-protein interactions

Abstract

Keeping harm at bay: In an in vitro strategy to prevent the cellular motility of oncogenic STAT3 protein, protein-membrane anchorage was induced by the use of a rationally designed cholesterol-based protein-membrane anchor in breast-tumor cells. (The fluorescence image shows the localization of the protein to the liposome boundary of a multilamellar vesicle.) Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication Date

7-4-2011

Publication Title

Angewandte Chemie - International Edition

Volume

50

Issue

28

Number of Pages

6248-6253

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/anie.201102486

Socpus ID

79959860214 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/79959860214

This document is currently not available here.

Share

COinS