Title

The C. Elegans Soxc Protein Sem-2 Opposes Differentiation Factors To Promote A Proliferative Blast Cell Fate In The Postembryonic Mesoderm

Keywords

Bodywall muscle; Differentiation; Hox; M lineage; Mesoderm; PBC; Proliferation; SEM-2; Sex myoblast; SoxC

Abstract

The proper development of multicellular organisms requires precise regulation and coordination of cell fate specification, cell proliferation and differentiation. Abnormal regulation and coordination of these processes could lead to disease, including cancer. We have examined the function of the sole C. elegans SoxC protein, SEM-2, in the M lineage, which produces the postembryonic mesoderm. We found that SEM-2/SoxC is both necessary and sufficient to promote a proliferating blast cell fate, the sex myoblast fate, over a differentiated striated bodywall muscle fate. A number of factors control the specific expression of sem-2 in the sex myoblast precursors and their descendants. This includes direct control of sem-2 expression by a Hox-PBC complex. The crucial nature of the HOX/PBC factors in directly enhancing expression of this proliferative factor in the C. elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation. © 2011. Published by The Company of Biologists Ltd.

Publication Date

3-1-2011

Publication Title

Development

Volume

138

Issue

6

Number of Pages

1033-1043

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1242/dev.062240

Socpus ID

79955127606 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/79955127606

This document is currently not available here.

Share

COinS